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REN Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: apical part of cell; extracellular region; extracellular space; plasma membrane
Molecular Function: aspartic-type endopeptidase activity; peptidase activity; receptor binding
Biological Process: angiotensin maturation; kidney development; protein catabolic process; proteolysis; regulation of blood pressure; regulation of MAPKKK cascade
Disease: Hyperuricemic Nephropathy, Familial Juvenile, 2; Renal Tubular Dysgenesis
Reference #:  P00797 (UniProtKB)
Alt. Names/Synonyms: angiotensin-forming enzyme; Angiotensinogenase; FLJ10761; HNFJ2; REN; RENI; Renin; renin precursor, renal
Gene Symbols: REN
Molecular weight: 45,057 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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