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NKX2-2 Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 20p11.22
Cellular Component: nucleoplasm
Molecular Function: chromatin binding; transcription coactivator activity
Biological Process: brain development; endocrine pancreas development; positive regulation of transcription factor activity
Reference #:  O95096 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein NK-2 homolog B; Homeobox protein Nkx-2.2; NK-2 homolog B; NK2 homeobox 2; NK2 transcription factor related, locus 2; NK2 transcription factor-like protein B; NKX2-2; NKX2.2; NKX22; NKX2B
Gene Symbols: NKX2-2
Molecular weight: 30,133 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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