Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

NMDAR1 a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cell surface; dendrite; dendritic spine; excitatory synapse; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; synaptic vesicle; terminal button
Molecular Function: calcium channel activity; calcium ion binding; calmodulin binding; glutamate binding; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; neurotransmitter binding; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: calcium ion homeostasis; cation transport; ephrin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; propylene metabolic process; regulation of excitatory postsynaptic membrane potential; regulation of membrane potential; response to ethanol; visual learning
Disease: Mental Retardation, Autosomal Dominant 8
Reference #:  Q05586 (UniProtKB)
Alt. Names/Synonyms: glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; GRIN1; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA1; NMDAR1; NMDZ1; NR1
Gene Symbols: GRIN1
Molecular weight: 105,373 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein