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NFAT1 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. It is present in a phosphorylated the cytosol of unstimulated T cells. After T-cell activation, it is dephosphorylated by calcineurin and translocates to the nucleus as a part of a transcription complex. Two splice variant isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding; transcription factor activity
Biological Process: B cell receptor signaling pathway; cell migration; positive regulation of B cell proliferation; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to drug
Reference #:  Q13469 (UniProtKB)
Alt. Names/Synonyms: NF-ATc2; NF-ATp; NFAC2; NFAT pre-existing subunit; NFAT transcription complex, preexisting component; NFAT1; NFATC2; NFATP; Nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, preexisting component; preexisting nuclear factor of activated T-cells 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1
Gene Symbols: NFATC2
Molecular weight: 100,146 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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