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MOR-1 a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6q25.2
Cellular Component: axon; dendrite; endoplasmic reticulum; endosome; Golgi apparatus; integral to plasma membrane; neuron projection; plasma membrane
Molecular Function: beta-endorphin receptor activity; G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; neuropeptide binding; protein binding; voltage-gated calcium channel activity
Biological Process: behavioral response to ethanol; cellular response to stress; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of adenylate cyclase activity; negative regulation of cell proliferation; positive regulation of neurogenesis; sensory perception of pain; synaptic transmission
Disease: Epilepsy, Idiopathic Generalized
Reference #:  P35372 (UniProtKB)
Alt. Names/Synonyms: hMOP; KIAA0403; LMOR; M-OR-1; MOP; MOR; MOR-1; MOR1; Mu opiate receptor; Mu opioid receptor; Mu-type opioid receptor; opioid receptor, mu 1; OPRM; OPRM1
Gene Symbols: OPRM1
Molecular weight: 44,779 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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