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Moesin a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq12
Cellular Component: apical part of cell; apical plasma membrane; cell surface; cytoplasm; cytoskeleton; cytosol; extracellular space; filopodium; focal adhesion; microvillus; nucleus; perinuclear region of cytoplasm; plasma membrane; pseudopodium; vesicle
Molecular Function: cell adhesion molecule binding; double-stranded RNA binding; enzyme binding; protein binding; protein kinase binding; receptor binding; structural constituent of cytoskeleton
Biological Process: cell motility; establishment of epithelial cell polarity; formation of immunological synapse; gland morphogenesis; leukocyte adhesion; leukocyte migration; membrane to membrane docking; regulation of cell shape; regulation of cell size; T cell proliferation
Disease: Immunodeficiency 50
Reference #:  P26038 (UniProtKB)
Alt. Names/Synonyms: Membrane-organizing extension spike protein; MOES; Moesin; MSN
Gene Symbols: MSN
Molecular weight: 67,820 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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