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SCD Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Belongs to the fatty acid desaturase family. Note: This description may include information from UniProtKB.
Protein type: EC; Endoplasmic reticulum; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q24.31
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; nucleolus
Molecular Function: iron ion binding; oxidoreductase activity; stearoyl-CoA 9-desaturase activity
Biological Process: acyl-CoA biosynthetic process; regulation of cholesterol biosynthetic process; unsaturated fatty acid biosynthetic process
Reference #:  O00767 (UniProtKB)
Alt. Names/Synonyms: ACOD; Acyl-CoA desaturase; Delta(9)-desaturase; delta-9-desaturase; FADS5; Fatty acid desaturase; MSTP008; predicted protein of HQ0998; SCD; SCD1; SCDOS; Stearoyl-CoA desaturase; stearoyl-CoA desaturase (delta-9-desaturase); stearoyl-CoA desaturase opposite strand
Gene Symbols: SCD
Molecular weight: 41,523 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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