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PARN 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Homodimer. Interacts with KHSRP and CELF1/CUGBP1. Found in a mRNA decay complex with RENT1, RENT2 and RENT3B. Ubiquitous. Belongs to the CAF1 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleolus; RNA-binding; Ribonuclease
Chromosomal Location of Human Ortholog: 16p13.12
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: cation binding; mRNA 3'-UTR binding; nuclease activity; poly(A)-specific ribonuclease activity; protein binding; protein kinase binding; RNA binding
Biological Process: female gamete generation; poly(A) tail shortening; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; regulation of mRNA stability; RNA modification
Disease: Dyskeratosis Congenita, Autosomal Recessive, 6; Pulmonary Fibrosis And/or Bone Marrow Failure, Telomere-related, 4
Reference #:  O95453 (UniProtKB)
Alt. Names/Synonyms: DAN; Deadenylating nuclease; Deadenylation nuclease; PARN; poly(A)-specific ribonuclease (deadenylation nuclease); Poly(A)-specific ribonuclease PARN; Polyadenylate-specific ribonuclease
Gene Symbols: PARN
Molecular weight: 73,451 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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