ACP5 Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - riboflavin; EC; Motility/polarity/chemotaxis; Phosphatase
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component:  cytosol; integral component of membrane; lysosome
Molecular Function:  ferric iron binding; ferrous iron binding
Biological Process:  bone morphogenesis; defense response to Gram-positive bacterium; dephosphorylation; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; negative regulation of nitric oxide biosynthetic process; negative regulation of superoxide anion generation; negative regulation of tumor necrosis factor production; response to cytokine; response to lipopolysaccharide; riboflavin metabolic process
Disease: Spondyloenchondrodysplasia With Immune Dysregulation
Reference #:  P13686 (UniProtKB)
Alt. Names/Synonyms: acid phosphatase 5, tartrate resistant; ACP5; HPAP; human purple acid phosphatase; MGC117378; PPA5; Tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase 5a; tartrate-resistant acid phosphatase 5b; Tartrate-resistant acid phosphatase type 5; TR-AP; TRACP5a; TRACP5b; TRAP; TrATPase; Type 5 acid phosphatase
Gene Symbols: ACP5
Molecular weight: 36,599 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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