AARS Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Aminoacyl-tRNA synthetase; EC; Ligase; RNA-binding; Translation; Translation regulation
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component:  cytoplasm; cytosol; mitochondrion
Molecular Function:  alanine-tRNA ligase activity; amino acid binding; aminoacyl-tRNA editing activity; aminoacyl-tRNA ligase activity; ATP binding; ligase activity; metal ion binding; nucleic acid binding; nucleotide binding; protein binding; RNA binding; Ser-tRNA(Ala) hydrolase activity; translation regulator activity; tRNA binding
Biological Process:  alanyl-tRNA aminoacylation; cerebellar Purkinje cell layer development; negative regulation of neuron apoptotic process; neuromuscular process; neuromuscular process controlling balance; regulation of cytoplasmic translational fidelity; translation; tRNA aminoacylation; tRNA modification
Reference #:  Q8BGQ7 (UniProtKB)
Alt. Names/Synonyms: Aars; Aars1; AI316495; Alanine--tRNA ligase; Alanine--tRNA ligase, cytoplasmic; alanyl-tRNA synthetase; Alanyl-tRNA synthetase, cytoplasmic; AlaRS; C76919; MGC37368; Protein sticky; sti; SYAC
Gene Symbols: Aars
Molecular weight: 106,909 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene