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TPM2
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. Belongs to the tropomyosin family. Present in primary breast cancer tissue, absent from normal breast tissue. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of human Ortholog: 9p13.3 |
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Cellular Component:
actin cytoskeleton; actin filament; cytosol; muscle thin filament tropomyosin
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Molecular Function:
actin binding; actin filament binding; identical protein binding; protein heterodimerization activity; protein homodimerization activity; structural constituent of muscle
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Biological Process:
actin filament organization; muscle contraction; regulation of ATP-dependent activity
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Disease: Arthrogryposis, Distal, Type 1a; Nemaline Myopathy 4
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Reference #:
P07951
(UniProtKB)
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Alt. Names/Synonyms: AMCD1; Beta-tropomyosin; DA1; DA2B; DA2B4; epididymis secretory protein Li 273; HEL-S-273; NEM4; nemaline myopathy type 4; TMSB; TPM2; tropomyosin 2; tropomyosin 2 (beta); Tropomyosin beta chain; Tropomyosin-2
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Gene Symbols: TPM2
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Molecular weight:
32,851 Da
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Basal Isoelectric point:
4.66
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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