TPM2 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. Belongs to the tropomyosin family. Present in primary breast cancer tissue, absent from normal breast tissue. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of human Ortholog: 9p13.3
Cellular Component:  actin cytoskeleton; actin filament; cytosol; muscle thin filament tropomyosin
Molecular Function:  actin binding; actin filament binding; identical protein binding; protein heterodimerization activity; protein homodimerization activity; structural constituent of muscle
Biological Process:  actin filament organization; muscle contraction; regulation of ATP-dependent activity
Disease: Arthrogryposis, Distal, Type 1a; Nemaline Myopathy 4
Reference #:  P07951 (UniProtKB)
Alt. Names/Synonyms: AMCD1; Beta-tropomyosin; DA1; DA2B; DA2B4; epididymis secretory protein Li 273; HEL-S-273; NEM4; nemaline myopathy type 4; TMSB; TPM2; tropomyosin 2; tropomyosin 2 (beta); Tropomyosin beta chain; Tropomyosin-2
Gene Symbols: TPM2
Molecular weight: 32,851 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein