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Claudin-18
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Belongs to the claudin family. Isoform A1: Expression is restricted to the lung (PubMed:19047087). Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level) (PubMed:19047087). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 3q22.3 |
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Cellular Component:
bicellular tight junction; lateral plasma membrane; plasma membrane
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Molecular Function:
identical protein binding; protein binding; structural molecule activity
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Biological Process:
bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell adhesion; digestive tract development; negative regulation of bone resorption; negative regulation of osteoclast development; negative regulation of protein localization to nucleus; protein localization to nucleus; response to ethanol; TNFSF11-mediated signaling pathway
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Reference #:
P56856
(UniProtKB)
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Alt. Names/Synonyms: claudin 18; Claudin-18; claudin18; CLD18; CLDN18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J
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Gene Symbols: CLDN18
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Molecular weight:
27,856 Da
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Basal Isoelectric point:
8.39
Predict pI for various phosphorylation states
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