Claudin-18 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Belongs to the claudin family. Isoform A1: Expression is restricted to the lung (PubMed:19047087). Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level) (PubMed:19047087). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 3q22.3
Cellular Component:  bicellular tight junction; integral component of membrane; plasma membrane
Molecular Function:  identical protein binding; structural molecule activity
Biological Process:  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; digestive tract development; negative regulation of bone resorption; negative regulation of osteoclast development; negative regulation of protein localization to nucleus; response to ethanol; TNFSF11-mediated signaling pathway
Reference #:  P56856 (UniProtKB)
Alt. Names/Synonyms: claudin 18; Claudin-18; claudin18; CLD18; CLDN18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J
Gene Symbols: CLDN18
Molecular weight: 27,856 Da
Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein