ASPM Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 1|1 E4-F
Cellular Component:  apical plasma membrane; centrosome; cytoplasm; cytoskeleton; meiotic spindle; microtubule; microtubule minus-end; midbody; mitotic spindle pole; nucleus; spindle pole
Molecular Function:  calmodulin binding
Biological Process:  brain development; cell cycle; cell division; cerebral cortex development; developmental growth; forebrain neuroblast division; maintenance of centrosome location; male gonad development; negative regulation of asymmetric cell division; negative regulation of neuron differentiation; neuron migration; neuronal stem cell population maintenance; oogenesis; positive regulation of canonical Wnt signaling pathway; positive regulation of neuroblast proliferation; regulation of meiotic cell cycle; spermatogenesis; spindle assembly involved in meiosis; spindle localization; spindle organization
Reference #:  Q8CJ27 (UniProtKB)
Alt. Names/Synonyms: abnormal spindle microtubule assembly; Abnormal spindle-like microcephaly-associated protein homolog; asp (abnormal spindle)-like, microcephaly associated; asp (abnormal spindle)-like, microcephaly associated (Drosophila); Aspm; Calm; Calmbp1; calmodulin binding protein 1; Calmodulin-binding protein 1; Calmodulin-binding protein Sha1; D330028K02Rik; FLJ10518; MCPH; MCPH5; OTTMUSP00000021198; Sha1; Spindle and hydroxyurea checkpoint abnormal protein
Gene Symbols: Aspm
Molecular weight: 364,218 Da
Basal Isoelectric point: 10.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein