MEF2C transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5q14.3
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; nucleus; postsynapse; protein-containing complex; sarcoplasm
Molecular Function:  activating transcription factor binding; AT DNA binding; chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding; protein binding; protein heterodimerization activity; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  apoptotic process; B cell homeostasis; B cell proliferation; B cell receptor signaling pathway; blood vessel development; blood vessel remodeling; cardiac muscle hypertrophy in response to stress; cardiac ventricle formation; cartilage morphogenesis; cell morphogenesis involved in neuron differentiation; cellular response to calcium ion; cellular response to drug; cellular response to fluid shear stress; cellular response to lipopolysaccharide; cellular response to parathyroid hormone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to trichostatin A; chondrocyte differentiation; embryonic viscerocranium morphogenesis; endochondral ossification; epithelial cell proliferation involved in renal tubule morphogenesis; excitatory postsynaptic potential; germinal center formation; glomerulus morphogenesis; heart development; heart looping; humoral immune response; learning or memory; MAPK cascade; melanocyte differentiation; monocyte differentiation; muscle cell fate determination; muscle organ development; myotube differentiation; negative regulation of blood vessel endothelial cell migration; negative regulation of gene expression; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of transcription by RNA polymerase II; negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular endothelial cell proliferation; negative regulation of vascular smooth muscle cell proliferation; nephron tubule epithelial cell differentiation; nervous system development; neural crest cell differentiation; neuron development; neuron differentiation; neuron migration; osteoblast differentiation; outflow tract morphogenesis; platelet formation; positive regulation of alkaline phosphatase activity; positive regulation of B cell proliferation; positive regulation of behavioral fear response; positive regulation of bone mineralization; positive regulation of cardiac muscle cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation in bone marrow; positive regulation of gene expression; positive regulation of macrophage apoptotic process; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of protein homodimerization activity; positive regulation of skeletal muscle cell differentiation; positive regulation of skeletal muscle tissue development; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; primary heart field specification; regulation of AMPA receptor activity; regulation of dendritic spine development; regulation of germinal center formation; regulation of megakaryocyte differentiation; regulation of neuron apoptotic process; regulation of neurotransmitter secretion; regulation of NMDA receptor activity; regulation of sarcomere organization; regulation of synapse assembly; regulation of synaptic activity; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; regulation of transcription, DNA-templated; renal tubule morphogenesis; roof of mouth development; secondary heart field specification; sinoatrial valve morphogenesis; skeletal muscle cell differentiation; skeletal muscle tissue development; smooth muscle cell differentiation; ventricular cardiac muscle cell differentiation
Disease: Mental Retardation, Autosomal Dominant 20
Reference #:  Q06413 (UniProtKB)
Alt. Names/Synonyms: MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C); MEF2C; myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C
Gene Symbols: MEF2C
Molecular weight: 51,221 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein