ASPM Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 1q31.3
Cellular Component:  apical plasma membrane; centrosome; cytoplasm; meiotic spindle; microtubule minus-end; midbody; mitotic spindle pole; nucleus
Molecular Function:  calmodulin binding
Biological Process:  asymmetric cell division; cerebral cortex development; developmental growth; forebrain neuroblast division; maintenance of centrosome location; male gonad development; meiotic spindle assembly; negative regulation of asymmetric cell division; negative regulation of neuron differentiation; neuron migration; neuronal stem cell population maintenance; oogenesis; positive regulation of canonical Wnt signaling pathway; positive regulation of neuroblast proliferation; regulation of meiotic cell cycle; spermatogenesis; spindle localization; spindle organization
Disease: Microcephaly 5, Primary, Autosomal Recessive
Reference #:  Q8IZT6 (UniProtKB)
Alt. Names/Synonyms: abnormal spindle microtubule assembly; Abnormal spindle protein homolog; Abnormal spindle-like microcephaly-associated protein; ASP; asp (abnormal spindle) homolog, microcephaly associated; asp (abnormal spindle) homolog, microcephaly associated (Drosophila); asp (abnormal spindle)-like, microcephaly associated; Asp homolog; ASPM; assembly factor for spindle microtubules; Calmbp1; DKFZp686N06184; FLJ10517; FLJ10549; FLJ43117; MCPH5
Gene Symbols: ASPM
Molecular weight: 409,800 Da
Basal Isoelectric point: 10.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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