GAS8 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner. Belongs to the DRC4 family. Expressed in respiratory epithelial cells (at protein level) (PubMed:26387594). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney (PubMed:9790751). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 8|8 E1
Cellular Component:  9+2 motile cilium; axoneme; cell projection; ciliary basal body; cilium; cytoplasm; cytoskeleton; Golgi apparatus; microtubule; microtubule cytoskeleton; motile cilium; sperm flagellum
Molecular Function:  microtubule binding; protein binding; Rab GTPase binding
Biological Process:  axoneme assembly; brain development; cell motility; cellular protein localization; cilium movement involved in cell motility; determination of left/right symmetry; epithelial cilium movement; flagellated sperm motility; positive regulation of protein localization to cilium; positive regulation of smoothened signaling pathway; regulation of microtubule binding
Reference #:  Q60779 (UniProtKB)
Alt. Names/Synonyms: beta growth arrest specific protein 11; DRC4; Dynein regulatory complex subunit 4; Gas; GAS-11; GAS-8; Gas11; Gas8; growth arrest specific 11; growth arrest specific 8; growth arrest specific protein 11; Growth arrest-specific protein 11; Growth arrest-specific protein 8
Gene Symbols: Gas8
Molecular weight: 56,264 Da
Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene