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SCRT1
Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation. Belongs to the snail C2H2-type zinc-finger protein family. Brain specific. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 15|15 D3 |
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Cellular Component:
nuclear body; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of neuron migration
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Reference #:
Q99M85
(UniProtKB)
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Alt. Names/Synonyms: mScrt; Scratch 1; scratch family zinc finger 1; Scratch homolog 1 zinc finger protein; scratch homolog 1, zinc finger protein; scratch homolog 1, zinc finger protein (Drosophila); SCRT; Scrt1; Transcriptional repressor scratch 1
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Gene Symbols: Scrt1
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Molecular weight:
35,919 Da
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Basal Isoelectric point:
9.62
Predict pI for various phosphorylation states
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