GAS8 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner. Belongs to the DRC4 family. Expressed in respiratory epithelial cells (at protein level) (PubMed:26387594). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney (PubMed:9790751). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of human Ortholog: 16q24.3
Cellular Component:  axoneme; ciliary basal body; cilium; microtubule; motile cilium; sperm flagellum
Molecular Function:  microtubule binding; protein binding
Biological Process:  axoneme assembly; brain development; cilium movement involved in cell motility; determination of left/right symmetry; epithelial cilium movement; flagellated sperm motility; negative regulation of cell proliferation; positive regulation of protein localization to cilium; positive regulation of smoothened signaling pathway; regulation of microtubule binding
Disease: Ciliary Dyskinesia, Primary, 33
Reference #:  O95995 (UniProtKB)
Alt. Names/Synonyms: CILD33; DRC4; Dynein regulatory complex subunit 4; epididymis secretory sperm binding protein; GAS-11; GAS-8; GAS11; GAS8; growth arrest specific 11; growth arrest specific 8; growth arrest-specific 11; growth arrest-specific 8; Growth arrest-specific protein 11; Growth arrest-specific protein 8; MGC138326
Gene Symbols: GAS8
Molecular weight: 56,356 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene