PTPRF Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component:  integral component of plasma membrane; neuron projection; neuronal cell body; plasma membrane
Molecular Function:  cell adhesion molecule binding; chondroitin sulfate proteoglycan binding; heparin binding; protein tyrosine phosphatase activity; protein-containing complex binding; transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  cell adhesion; cell migration; negative regulation of receptor binding; neuron projection regeneration; peptidyl-tyrosine dephosphorylation; regulation of axon regeneration; synaptic membrane adhesion; transmembrane receptor protein tyrosine phosphatase signaling pathway
Disease: Breasts And/or Nipples, Aplasia Or Hypoplasia Of, 2
Reference #:  P10586 (UniProtKB)
Alt. Names/Synonyms: FLJ43335; FLJ45062; FLJ45567; LAR; LCA-homolog; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; Leukocyte common antigen related; protein tyrosine phosphatase, receptor type, F; protein tyrosine phosphatase, receptor type, F polypeptide; PTPRF; receptor-linked protein-tyrosine phosphatase LAR; Receptor-type tyrosine-protein phosphatase F
Gene Symbols: PTPRF
Molecular weight: 212,879 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein