Claudin-7 Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 11|11 B3
Cellular Component:  anchoring junction; apicolateral plasma membrane; basolateral plasma membrane; bicellular tight junction; lateral plasma membrane; membrane; plasma membrane
Molecular Function:  cell adhesion molecule binding; protein binding; protein domain specific binding; structural molecule activity
Biological Process:  bicellular tight junction assembly; cell adhesion; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of protein-containing complex assembly; positive regulation of cell motility; positive regulation of cell population proliferation
Reference #:  Q9Z261 (UniProtKB)
Alt. Names/Synonyms: claudin 7; Claudin-7; claudin7; CLD7; Cldn7; OTTMUSP00000006253; OTTMUSP00000017071
Gene Symbols: Cldn7
Molecular weight: 22,359 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein