Claudin-7 Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11|11 B3
Cellular Component:  apicolateral plasma membrane; basolateral plasma membrane; bicellular tight junction; cell junction; integral component of membrane; lateral plasma membrane; membrane; plasma membrane
Molecular Function:  cell adhesion molecule binding; protein binding; structural molecule activity
Biological Process:  negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of protein homooligomerization; positive regulation of cell motility; positive regulation of cell proliferation
Reference #:  Q9Z261 (UniProtKB)
Alt. Names/Synonyms: claudin 7; Claudin-7; claudin7; CLD7; Cldn7; OTTMUSP00000006253; OTTMUSP00000017071
Gene Symbols: Cldn7
Molecular weight: 22,359 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
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Claudin-7

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene