GGH Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Belongs to the peptidase C26 family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4|4 A3
Cellular Component:  cytosol; extracellular region; extracellular space; lysosome; vacuole
Molecular Function:  gamma-glutamyl-peptidase activity; hydrolase activity; omega peptidase activity; peptidase activity
Biological Process:  response to drug; response to ethanol; response to insulin; response to zinc ion; tetrahydrofolylpolyglutamate metabolic process
Reference #:  Q9Z0L8 (UniProtKB)
Alt. Names/Synonyms: Conjugase; FGPH; Folylpolyglutamate hydrolase; gamma-GH; Gamma-Glu-x carboxypeptidase; Gamma-glutamyl hydrolase; Ggh; GH
Gene Symbols: Ggh
Molecular weight: 35,470 Da
Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene