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GGH
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Belongs to the peptidase C26 family. Note: This description may include information from UniProtKB.
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| Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.4.19.9; Protease; Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 4|4 A3 |
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Cellular Component:
extracellular region; extracellular space; lysosome; vacuole
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Molecular Function:
gamma-glutamyl-peptidase activity; hydrolase activity; omega peptidase activity; peptidase activity
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Biological Process:
response to ethanol; response to insulin; response to xenobiotic stimulus; response to zinc ion; tetrahydrofolylpolyglutamate metabolic process
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Reference #:
Q9Z0L8
(UniProtKB)
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Alt. Names/Synonyms: Conjugase; FGPH; Folylpolyglutamate hydrolase; gamma-; gamma-GH; Gamma-Glu-x carboxypeptidase; Gamma-glutamyl hydrolase; Ggh; GH
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Gene Symbols: Ggh
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Molecular weight:
35,470 Da
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Basal Isoelectric point:
7.09
Predict pI for various phosphorylation states
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