GGH Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Belongs to the peptidase C26 family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.4.19.9; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q12.3
Cellular Component:  azurophil granule lumen; cytosol; extracellular region; extracellular space; melanosome; specific granule lumen; tertiary granule lumen
Molecular Function:  exopeptidase activity; gamma-glutamyl-peptidase activity; omega peptidase activity
Biological Process:  neutrophil degranulation; proteolysis; response to ethanol; response to insulin; response to zinc ion
Reference #:  Q92820 (UniProtKB)
Alt. Names/Synonyms: Conjugase; folylpolygammaglutamyl hydrolase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); GGH; GH
Gene Symbols: GGH
Molecular weight: 35,964 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
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GGH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene