GGH
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Belongs to the peptidase C26 family. Note: This description may include information from UniProtKB.
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Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.4.19.9; Protease; Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 8q12.3 |
Cellular Component:
azurophil granule lumen; extracellular region; extracellular space; melanosome; specific granule lumen; tertiary granule lumen; vacuole
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Molecular Function:
exopeptidase activity; gamma-glutamyl-peptidase activity; omega peptidase activity; protein binding
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Biological Process:
tetrahydrofolylpolyglutamate metabolic process
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Reference #:
Q92820
(UniProtKB)
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Alt. Names/Synonyms: Conjugase; folylpolygammaglutamyl hydrolase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); GGH; GH
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Gene Symbols: GGH
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Molecular weight:
35,964 Da
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Basal Isoelectric point:
6.66
Predict pI for various phosphorylation states
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