ARSA Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Lipid Metabolism - sphingolipid
Chromosomal Location of human Ortholog: 22q13.33
Cellular Component:  azurophil granule lumen; endoplasmic reticulum lumen; extracellular region; lysosomal lumen; lysosome
Molecular Function:  arylsulfatase activity; calcium ion binding; cerebroside-sulfatase activity; protein binding; sulfuric ester hydrolase activity
Biological Process:  lipid metabolic process
Disease: Metachromatic Leukodystrophy
Reference #:  P15289 (UniProtKB)
Alt. Names/Synonyms: ARSA; Arylsulfatase A; Arylsulfatase A component B; Arylsulfatase A component C; ASA; Cerebroside-sulfatase; epididymis secretory sperm binding protein; MLD
Gene Symbols: ARSA
Molecular weight: 53,588 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB