IGBP1
Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. Belongs to the IGBP1/TAP42 family. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Note: This description may include information from UniProtKB.
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Protein type: Motility/polarity/chemotaxis; Phosphatase, regulatory subunit |
Chromosomal Location of human Ortholog: Xq13.1 |
Cellular Component:
cytoplasm; cytosol
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Molecular Function:
protein binding; protein phosphatase 2A binding; protein phosphatase regulator activity
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Biological Process:
B cell activation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; regulation of dephosphorylation; regulation of microtubule-based movement; response to interleukin-1; response to tumor necrosis factor; signal transduction
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Disease: Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia
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Reference #:
P78318
(UniProtKB)
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Alt. Names/Synonyms: ALPHA-4; alpha4; B cell signal transduction molecule alpha 4; B-cell signal transduction molecule alpha 4; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) ); CD79a-binding protein 1; IBP1; IGBP1; immunoglobulin (CD79A) binding protein 1; immunoglobulin binding protein 1; Immunoglobulin-binding protein 1; Protein alpha-4; Protein phosphatase 2/4/6 regulatory subunit; protein phosphatase 2A, regulatory subunit alpha-4; Renal carcinoma antigen NY-REN-16
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Gene Symbols: IGBP1
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Molecular weight:
39,222 Da
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Basal Isoelectric point:
5.26
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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