|
POR
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Note: This description may include information from UniProtKB.
|
| Protein type: EC 1.6.2.4; Endoplasmic reticulum; Mitochondrial; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 5 G2|5 75.34 cM |
|
Cellular Component:
cytosol; endoplasmic reticulum; intracellular membrane-bounded organelle; membrane
|
|
Molecular Function:
cytochrome-b5 reductase activity, acting on NAD(P)H; electron transfer activity; enzyme binding; flavin adenine dinucleotide binding; FMN binding; hydrolase activity; iron-cytochrome-c reductase activity; NADP binding; NADPH-hemoprotein reductase activity; nitric oxide dioxygenase activity; oxidoreductase activity
|
|
Biological Process:
cellular organofluorine metabolic process; demethylation; electron transport chain; fatty acid oxidation; internal peptidyl-lysine acetylation; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of lipase activity; nitrate catabolic process; nitric oxide catabolic process; positive regulation of cholesterol biosynthetic process; positive regulation of chondrocyte differentiation; positive regulation of monooxygenase activity; positive regulation of smoothened signaling pathway; positive regulation of steroid hormone biosynthetic process; regulation of cholesterol metabolic process; regulation of growth plate cartilage chondrocyte proliferation; response to dexamethasone; response to hormone
|
|
Reference #:
P37040
(UniProtKB)
|
|
Alt. Names/Synonyms: 4933424M13Rik; CPR; CYPOR; NADH cytochrome P450 oxydoreductase; NADPH--cytochrome P450 reductase; NCPR; P450 (cytochrome) oxidoreductase; P450R; Por
|
|
Gene Symbols: Por
|
|
Molecular weight:
77,044 Da
|
|
Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
|
