POR This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Note: This description may include information from UniProtKB.
Protein type: EC; Endoplasmic reticulum; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 7q11.23
Cellular Component:  cytosol; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; mitochondrion
Molecular Function:  cytochrome-b5 reductase activity, acting on NAD(P)H; electron transfer activity; enzyme binding; flavin adenine dinucleotide binding; FMN binding; hydrolase activity; iron-cytochrome-c reductase activity; NADP binding; NADPH-hemoprotein reductase activity; nitric oxide dioxygenase activity; oxidoreductase activity; protein binding
Biological Process:  carnitine metabolic process; cellular organofluorine metabolic process; cellular response to follicle-stimulating hormone stimulus; cellular response to peptide hormone stimulus; demethylation; electron transport chain; fatty acid oxidation; flavonoid metabolic process; internal peptidyl-lysine acetylation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of lipase activity; nitrate catabolic process; nitric oxide catabolic process; positive regulation of cholesterol biosynthetic process; positive regulation of chondrocyte differentiation; positive regulation of monooxygenase activity; positive regulation of smoothened signaling pathway; positive regulation of steroid hormone biosynthetic process; regulation of growth plate cartilage chondrocyte proliferation; response to dexamethasone; response to hormone; response to nutrient; xenobiotic metabolic process
Disease: Antley-bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis; Antley-bixler Syndrome Without Genital Anomalies Or Disordered Steroidogenesis; Disordered Steroidogenesis Due To Cytochrome P450 Oxidoreductase Deficiency
Reference #:  P16435 (UniProtKB)
Alt. Names/Synonyms: CPR; CYPOR; cytochrome p450 oxidoreductase; DKFZp686G04235; FLJ26468; NADPH--cytochrome P450 reductase; NADPH--hemoprotein reductase; NADPH-dependent cytochrome P450 reductase; NCPR; P450 (cytochrome) oxidoreductase; P450R; POR
Gene Symbols: POR
Molecular weight: 76,690 Da
Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB