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MARCKS
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. Belongs to the MARCKS family. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 6q21 |
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Cellular Component:
actin cytoskeleton; actin filament bundle; cell cortex; centrosome; cytoplasm; germinal vesicle; plasma membrane
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Molecular Function:
actin filament binding; calmodulin binding; identical protein binding; protein kinase C binding
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Biological Process:
actin crosslink formation; actin filament bundle assembly; actin filament organization; apoptotic process; central nervous system development; mitochondrion organization; neural tube development; neurogenesis; response to endoplasmic reticulum stress
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Reference #:
P29966
(UniProtKB)
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Alt. Names/Synonyms: 80K-L; 80K-L protein; FLJ14368; FLJ90045; MACS; MARCKS; MARCS; myristoylated alanine rich protein kinase C substrate; Myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich protein kinase C substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; PKCSL; PRKCSL; Protein kinase C substrate, 80 kDa protein, light chain
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Gene Symbols: MARCKS
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Molecular weight:
31,555 Da
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Basal Isoelectric point:
4.47
Predict pI for various phosphorylation states
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CST Pathways:
Protein Kinase C Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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