MALT1 Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Belongs to the peptidase C14B family. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 18q21.32
Cellular Component:  CBM complex; cytoplasm; cytosol; fibrillar center; nucleus; perinuclear region of cytoplasm; polkadots; protein-containing complex
Molecular Function:  cysteine-type endopeptidase activity; endopeptidase activity; identical protein binding; kinase activator activity; peptidase activity; protease binding; protein binding; protein self-association; small molecule binding; ubiquitin-protein transferase activity
Biological Process:  activation of NF-kappaB-inducing kinase activity; B cell activation; B-1 B cell differentiation; defense response; innate immune response; lipopolysaccharide-mediated signaling pathway; negative regulation of apoptotic process; nuclear export; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of interleukin-1 beta production; positive regulation of interleukin-2 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein ubiquitination; positive regulation of T cell cytokine production; positive regulation of T-helper 17 cell differentiation; proteolysis; proteolysis involved in protein catabolic process; regulation of apoptotic process; regulation of T cell receptor signaling pathway; response to fungus; T cell proliferation; T cell receptor signaling pathway
Disease: Immunodeficiency 12
Reference #:  Q9UDY8 (UniProtKB)
Alt. Names/Synonyms: caspase-like protein; DKFZp434L132; IMD12; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MALT1; MALT1 paracaspase; MALT1 protease; MLT; MLT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Paracaspase; paracaspase-1; PCASP1
Gene Symbols: MALT1
Molecular weight: 92,272 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein