LRRC17 Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors. Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component:  extracellular space
Biological Process:  bone marrow development; negative regulation of osteoclast differentiation
Reference #:  Q8N6Y2 (UniProtKB)
Alt. Names/Synonyms: 37 kDa leucine-rich repeat (LRR) protein; leucine rich repeat containing 17; Leucine-rich repeat-containing protein 17; LRC17; LRRC17; P37NB
Gene Symbols: LRRC17
Molecular weight: 51,800 Da
Basal Isoelectric point: 8.5  Predict pI for various phosphorylation states
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LRRC17

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein