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LAT
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 16p11.2 |
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Cellular Component:
cell-cell junction; COP9 signalosome; Golgi apparatus; immunological synapse; integral component of membrane; mast cell granule; membrane raft; plasma membrane
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Molecular Function:
protein binding; protein kinase binding; SH3/SH2 adaptor activity
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Biological Process:
adaptive immune response; calcium-mediated signaling; Fc-epsilon receptor signaling pathway; gene expression; immune response; integrin-mediated signaling pathway; intracellular signal transduction; lymphocyte homeostasis; MAPK cascade; mast cell degranulation; positive regulation of protein kinase activity; positive regulation of signal transduction; Ras protein signal transduction; regulation of T cell activation; T cell activation; T cell receptor signaling pathway
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Disease: Immunodeficiency 52
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Reference #:
O43561
(UniProtKB)
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Alt. Names/Synonyms: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; LAT; LAT1; linker for activation of T cells; Linker for activation of T-cells family member 1; p36-38; pp36
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Gene Symbols: LAT
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Molecular weight:
27,930 Da
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Basal Isoelectric point:
4.27
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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