AKR1C1
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. Belongs to the aldo/keto reductase family. Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain. Note: This description may include information from UniProtKB.
Protein type: EC 1.1.1.112; EC 1.1.1.149; EC 1.3.1.20; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of human Ortholog: 10p15.1
Cellular Component:
cytosol
Molecular Function:
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; 3beta-hydroxy-5beta-steroid dehydrogenase activity; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity; alditol:NADP+ 1-oxidoreductase activity; aldo-keto reductase (NADP) activity; androstan-3-alpha,17-beta-diol dehydrogenase activity; androsterone dehydrogenase (B-specific) activity; androsterone dehydrogenase activity; bile acid binding; carboxylic acid binding; dihydrotestosterone 17-beta-dehydrogenase activity; estradiol 17-beta-dehydrogenase [NAD(P)] activity; indanol dehydrogenase activity; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; protein binding; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; testosterone 17-beta-dehydrogenase (NADP+) activity; testosterone dehydrogenase [NAD(P)] activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Biological Process:
bile acid and bile salt transport; bile acid metabolic process; cellular response to jasmonic acid stimulus; cholesterol homeostasis; daunorubicin metabolic process; digestion; doxorubicin metabolic process; epithelial cell differentiation; intestinal cholesterol absorption; positive regulation of reactive oxygen species metabolic process; progesterone metabolic process; prostaglandin metabolic process; response to organophosphorus; retinal metabolic process; retinoid metabolic process; xenobiotic metabolic process
Reference #:
Q04828
(UniProtKB)
Alt. Names/Synonyms: 2-ALPHA-HSD; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; AK1C1; AKR1C1; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; C9; Chlordecone reductase homolog HAKRC; DD1; DD1/DD2; DDH; DDH1; dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase isoform DD1; H-37; HAKRC; HBAB; hepatic dihydrodiol dehydrogenase; High-affinity hepatic bile acid-binding protein; Indanol dehydrogenase; MBAB; MGC8954; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase
Gene Symbols: AKR1C1
Molecular weight:
36,788 Da
Basal Isoelectric point:
8.02
Predict pI for various phosphorylation states
Select Structure to View Below
AKR1C1
1MRQ - A=2-323 (human)
3C3U - A=1-323 (human)
3GUG - A=1-323 (human)
3NTY - A=1-323 (human)
4YVP - A/B=1-323 (human)
6A7A - A=1-323 (human)
6IJX - A=1-323 (human)
8JP2 - A=1-323 (human)