ALOX15 Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass. Belongs to the lipoxygenase family. Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Motility/polarity/chemotaxis; Oxidoreductase
Chromosomal Location of human Ortholog: 17p13.2
Cellular Component:  cytosol; extrinsic component of cytoplasmic side of plasma membrane; lipid droplet; membrane; plasma membrane
Molecular Function:  arachidonate 12(S)-lipoxygenase activity; arachidonate 15-lipoxygenase activity; iron ion binding; linoleate 13S-lipoxygenase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; phosphatidylinositol-4,5-bisphosphate binding; protein binding
Biological Process:  apoptotic cell clearance; arachidonic acid metabolic process; bone mineralization; cellular response to calcium ion; cellular response to interleukin-13; fatty acid oxidation; hepoxilin biosynthetic process; inflammatory response; linoleic acid metabolic process; lipid metabolic process; lipid oxidation; lipoxin A4 biosynthetic process; lipoxygenase pathway; long-chain fatty acid biosynthetic process; negative regulation of adaptive immune response; ossification; phosphatidylethanolamine biosynthetic process; positive regulation of actin filament polymerization; positive regulation of cell-substrate adhesion; positive regulation of ERK1 and ERK2 cascade; regulation of engulfment of apoptotic cell; regulation of inflammatory response; regulation of peroxisome proliferator activated receptor signaling pathway; response to endoplasmic reticulum stress; wound healing
Reference #:  P16050 (UniProtKB)
Alt. Names/Synonyms: 12-LOX; 12/15-lipoxygenase; 15-lipooxygenase-1; 15-lipoxygenase type 1; 15-LOX; 15-LOX type 1; 15-LOX-1; 15LOX-1; ALOX15; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; Hepoxilin A3 synthase Alox15; Linoleate 13S-lipoxygenase; LOG15; LOX15; Polyunsaturated fatty acid lipoxygenase ALOX15
Gene Symbols: ALOX15
Molecular weight: 74,804 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB