RND1 Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. Belongs to the small GTPase superfamily. Rho family. Mostly expressed in brain and liver. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component:  actin cytoskeleton; adherens junction; cytosol; intracellular membrane-bounded organelle; plasma membrane
Molecular Function:  GTPase activity; protein binding; signaling receptor binding
Biological Process:  actin filament organization; negative regulation of cell adhesion; neuron remodeling
Reference #:  Q92730 (UniProtKB)
Alt. Names/Synonyms: ARHS; FLJ42294; GTP-binding protein; ras homolog gene family, member S; Rho family GTPase 1; Rho-related GTP-binding protein Rho6; RHO6; RHOS; RND1
Gene Symbols: RND1
Molecular weight: 26,056 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
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Protein Structure Not Found.

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