ZNF143 a transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. Belongs to the GLI C2H2-type zinc-finger protein family. Expressed in all tissues tested, with the strongest expression in ovary. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of mouse Ortholog: 7 E3|7 57.7 cM
Cellular Component:  nucleus; PcG protein complex; transcription regulator complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process:  positive regulation of smooth muscle cell proliferation; positive regulation of snRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
Reference #:  O70230 (UniProtKB)
Alt. Names/Synonyms: AA959806; AU015869; D7Ertd805; D7Ertd805e; KRAB; KRAB14; mStaf; pHZ-; pHZ-1; SBF; selenocysteine tRNA gene transcription activating factor; Selenocysteine tRNA gene transcription-activating factor; Staf; Zfp-143; Zfp143; Zfp7; Zfp79; Zfp80-; Zfp80-rs1; Zinc finger protein 143; zinc finger protein 80, related sequence 1; ZN143; Znf143
Gene Symbols: Znf143
Molecular weight: 69,040 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene