TAX1BP1 Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Expressed in all tissues tested. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component:  cytosol
Molecular Function:  kinase binding; metal ion binding; protein binding
Biological Process:  apoptotic process; negative regulation of apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of type I interferon production; regulation of tumor necrosis factor-mediated signaling pathway
Reference #:  Q86VP1 (UniProtKB)
Alt. Names/Synonyms: CALCOCO3; T6BP; Tax1 (human T-cell leukemia virus type I) binding protein 1; Tax1 binding protein 1; Tax1-binding protein 1; TAX1BP1; TAXB1; TRAF6-binding protein; TXBP151
Gene Symbols: TAX1BP1
Molecular weight: 90,877 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TAX1BP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein