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TANK
Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; C2H2-type zinc finger protein |
| Chromosomal Location of Human Ortholog: 2q24.2 |
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Cellular Component:
cytosol; protein-containing complex
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Molecular Function:
deubiquitinase activator activity; metal ion binding; protein binding; ubiquitin protein ligase binding
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Biological Process:
cellular response to DNA damage stimulus; cellular response to interleukin-1; cellular response to ionizing radiation; cellular response to tumor necrosis factor; negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein deubiquitination; positive regulation of ubiquitin-specific protease activity; proteolysis; signal transduction; TRIF-dependent toll-like receptor signaling pathway; viral process
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Reference #:
Q92844
(UniProtKB)
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Alt. Names/Synonyms: I-TRAF; ITRAF; TANK; TRAF family member-associated NF-kappa-B activator; TRAF family member-associated NFKB activator; TRAF-interacting protein; TRAF2
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Gene Symbols: TANK
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Molecular weight:
47,816 Da
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Basal Isoelectric point:
5.46
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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