TANK Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; C2H2-type zinc finger protein
Chromosomal Location of human Ortholog: 2q24.2
Cellular Component:  cytosol; protein-containing complex
Molecular Function:  deubiquitinase activator activity; metal ion binding; protein binding; ubiquitin protein ligase binding
Biological Process:  cellular response to DNA damage stimulus; cellular response to interleukin-1; cellular response to ionizing radiation; cellular response to tumor necrosis factor; negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein deubiquitination; positive regulation of ubiquitin-specific protease activity; proteolysis; signal transduction; TRIF-dependent toll-like receptor signaling pathway; viral process
Reference #:  Q92844 (UniProtKB)
Alt. Names/Synonyms: I-TRAF; ITRAF; TANK; TRAF family member associated NFKB activator; TRAF family member-associated NF-kappa-B activator; TRAF family member-associated NFKB activator; TRAF-interacting protein; TRAF2
Gene Symbols: TANK
Molecular weight: 47,816 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein