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TANK
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; C2H2-type zinc finger protein |
| Chromosomal Location of human Ortholog: 2q24.2 |
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Cellular Component:
cytoplasm; cytosol; protein-containing complex; serine/threonine protein kinase complex
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Molecular Function:
cysteine-type deubiquitinase activity; deubiquitinase activator activity; metal ion binding; molecular adaptor activity; protein binding; ubiquitin protein ligase binding
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Biological Process:
cellular response to interleukin-1; cellular response to ionizing radiation; cellular response to tumor necrosis factor; defense response to virus; DNA damage response; I-kappaB kinase/NF-kappaB signaling; negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein deubiquitination; positive regulation of type I interferon production; positive regulation of ubiquitin-specific protease activity; signal transduction; type I interferon-mediated signaling pathway
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Reference #:
Q92844
(UniProtKB)
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Alt. Names/Synonyms: I-TRAF; ITRAF; TANK; TRAF family member associated NFKB activator; TRAF family member-associated NF-kappa-B activator; TRAF family member-associated NFKB activator; TRAF-interacting protein; TRAF2
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Gene Symbols: TANK
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Molecular weight:
47,816 Da
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Basal Isoelectric point:
5.46
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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