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SPT16
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Belongs to the peptidase M24 family. SPT16 subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: Transcription initiation complex |
| Chromosomal Location of human Ortholog: 14q11.2 |
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Cellular Component:
FACT complex; nucleoplasm; nucleus
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Molecular Function:
nucleosome binding; protein binding
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Biological Process:
DNA repair; DNA replication; nucleosome assembly; nucleosome disassembly; positive regulation of DNA-templated transcription, elongation; transcription by RNA polymerase II; transcription elongation by RNA polymerase II
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Disease: Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
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Reference #:
Q9Y5B9
(UniProtKB)
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Alt. Names/Synonyms: CDC68; Chromatin-specific transcription elongation factor 140 kDa subunit; facilitates chromatin remodeling 140 kDa subunit; Facilitates chromatin transcription complex subunit SPT16; FACT 140 kDa subunit; FACT complex subunit SPT16; FACT140; FACTP140; FLJ10857; FLJ14010; FLJ34357; hSPT16; SP16H; SPT16; SPT16 homolog, facilitates chromatin remodeling subunit; SPT16/CDC68; suppressor of Ty 16 homolog; suppressor of Ty 16 homolog (S. cerevisiae); SUPT16H
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Gene Symbols: SUPT16H
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Molecular weight:
119,914 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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