SPT16 Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Belongs to the peptidase M24 family. SPT16 subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of human Ortholog: 14q11.2
Cellular Component:  chromosome; nucleoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  DNA repair; DNA replication; nucleosome disassembly; positive regulation of DNA-templated transcription, elongation; regulation of signal transduction by p53 class mediator; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter
Disease: Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Reference #:  Q9Y5B9 (UniProtKB)
Alt. Names/Synonyms: CDC68; Chromatin-specific transcription elongation factor 140 kDa subunit; facilitates chromatin remodeling 140 kDa subunit; Facilitates chromatin transcription complex subunit SPT16; FACT 140 kDa subunit; FACT complex subunit SPT16; FACT140; FACTP140; FLJ10857; FLJ14010; FLJ34357; hSPT16; SP16H; SPT16; SPT16 homolog, facilitates chromatin remodeling subunit; SPT16/CDC68; suppressor of Ty 16 homolog; suppressor of Ty 16 homolog (S. cerevisiae); SUPT16H
Gene Symbols: SUPT16H
Molecular weight: 119,914 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SPT16

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB