SAP130 Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Belongs to the SAP130 family. Expressed in various cancer cell ines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Transcription factor
Chromosomal Location of Human Ortholog: 18|18 B1
Cellular Component:  nuclear speck; nucleus; Sin3-type complex
Molecular Function:  protein binding
Biological Process:  negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q8BIH0 (UniProtKB)
Alt. Names/Synonyms: 130 kDa Sin3-associated polypeptide; 2610304F09Rik; 6720406D06; Histone deacetylase complex subunit SAP130; Sap130; Sin3-associated polypeptide p130; Sin3A associated protein; Sin3A associated protein, 130kDa; SP130
Gene Symbols: Sap130
Molecular weight: 111,228 Da
Basal Isoelectric point: 9.91  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene