SAP130 Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Belongs to the SAP130 family. Expressed in various cancer cell ines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Transcription factor
Chromosomal Location of human Ortholog: 2q14.3
Cellular Component:  nuclear speck
Biological Process:  negative regulation of transcription by RNA polymerase II
Reference #:  Q9H0E3 (UniProtKB)
Alt. Names/Synonyms: 130 kDa Sin3-associated polypeptide; FLJ12761; Histone deacetylase complex subunit SAP130; mSin3A-associated protein 130; SAP130; Sin3-associated polypeptide p130; Sin3A associated protein 130; Sin3A associated protein 130kDa; Sin3A-associated protein, 130kDa; SP130
Gene Symbols: SAP130
Molecular weight: 110,324 Da
Basal Isoelectric point: 9.83  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein