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PPP1R1A
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. Belongs to the protein phosphatase inhibitor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Protein phosphatase, regulatory subunit |
| Chromosomal Location of human Ortholog: 12q13.2 |
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Cellular Component:
cytoplasm
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Molecular Function:
protein binding; protein serine/threonine phosphatase inhibitor activity
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Biological Process:
glycogen metabolic process; intracellular signal transduction
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Reference #:
Q13522
(UniProtKB)
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Alt. Names/Synonyms: I-1; I1; inhibitor-1; IPP-1; IPP1; PPP1R1A; PPR1A; protein phosphatase 1 regulatory inhibitor subunit 1A; Protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; Protein phosphatase inhibitor 1; protein phosphatase inhibitor-1
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Gene Symbols: PPP1R1A
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Molecular weight:
18,939 Da
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Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
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