PPP1R1A Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. Belongs to the protein phosphatase inhibitor 1 family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component:  extracellular space
Molecular Function:  protein binding; protein serine/threonine phosphatase inhibitor activity
Biological Process:  glycogen metabolic process; negative regulation of phosphoprotein phosphatase activity
Reference #:  Q13522 (UniProtKB)
Alt. Names/Synonyms: I-1; I1; inhibitor-1; IPP-1; IPP1; PPP1R1A; PPR1A; Protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; Protein phosphatase inhibitor 1; protein phosphatase inhibitor-1
Gene Symbols: PPP1R1A
Molecular weight: 19,011 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene