PLA2G4B
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine. Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.1.4; Lipid Metabolism - arachidonic acid; Phospholipase |
Chromosomal Location of mouse Ortholog: 2|2 E5 |
Cellular Component:
cytosol; early endosome membrane; mitochondrial inner membrane
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Molecular Function:
calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; lysophospholipase activity; phospholipase A1 activity; phospholipase A2 activity
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Biological Process:
glycerophospholipid catabolic process
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Reference #:
P0C871
(UniProtKB)
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Alt. Names/Synonyms: A030011C02Rik; cPLA2-beta; Cytosolic phospholipase A2 beta; Gm1013; MGC28892; OTTMUSP00000016276; PA24B; Phospholipase A2 group IVB; phospholipase A2, group IVB (cytosolic); Pla2g4b
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Gene Symbols: Pla2g4b
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Molecular weight:
88,448 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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