PLA2G4B Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine. Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.1.4; Lipid Metabolism - arachidonic acid; Phospholipase
Chromosomal Location of Human Ortholog: 2|2 E5
Cellular Component:  cytoplasm; cytosol
Molecular Function:  calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; lysophospholipase activity; phospholipase A2 activity
Biological Process:  glycerophospholipid catabolic process
Reference #:  P0C871 (UniProtKB)
Alt. Names/Synonyms: A030011C02Rik; cPLA2-beta; Cytosolic phospholipase A2 beta; Gm1013; MGC28892; OTTMUSP00000016276; PA24B; Phospholipase A2 group IVB; phospholipase A2, group IVB (cytosolic); Pla2g4b
Gene Symbols: Pla2g4b
Molecular weight: 88,448 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
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PLA2G4B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene