AACS Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - butanoate; EC; Ligase
Chromosomal Location of Human Ortholog: 5|5 G1.1
Cellular Component:  cell; cytoplasm; cytosol
Molecular Function:  acetoacetate-CoA ligase activity; ATP binding; butyrate-CoA ligase activity; catalytic activity; ligase activity; nucleotide binding
Biological Process:  cellular response to glucose stimulus; fatty acid metabolic process; lipid metabolic process; liver development; positive regulation of insulin secretion; response to drug; response to ethanol; response to nutrient; response to oleic acid; response to organic cyclic compound; response to organonitrogen compound
Reference #:  Q9D2R0 (UniProtKB)
Alt. Names/Synonyms: 2210408B16Rik; Aacs; Acetoacetyl-CoA synthetase; OTTMUSP00000027664; SUR5
Gene Symbols: Aacs
Molecular weight: 75,200 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene