AACS
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. Belongs to the ATP-dependent AMP-binding enzyme family. Highly expressed in kidney, heart and brain, but low in liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Carbohydrate Metabolism - butanoate; EC 6.2.1.16; Ligase |
Chromosomal Location of human Ortholog: 12q24.31 |
Cellular Component:
cytosol
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Molecular Function:
acetoacetate-CoA ligase activity; ATP binding; protein binding
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Biological Process:
fatty acid metabolic process; ketone body biosynthetic process; positive regulation of insulin secretion
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Reference #:
Q86V21
(UniProtKB)
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Alt. Names/Synonyms: AACS; acetoacetate-CoA ligase; Acetoacetyl-CoA synthetase; ACSF1; Acyl-CoA synthetase family member 1; FLJ12389; FLJ41251; homolog of C. elegans supressor of ras 5 (sur-5); Protein sur-5 homolog; SUR-5
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Gene Symbols: AACS
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Molecular weight:
75,144 Da
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Basal Isoelectric point:
5.86
Predict pI for various phosphorylation states
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