AACS Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - butanoate; EC; Ligase
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component:  cytosol
Molecular Function:  acetoacetate-CoA ligase activity; ATP binding; butyrate-CoA ligase activity; protein binding
Biological Process:  adipose tissue development; cellular response to cholesterol; cellular response to glucose stimulus; cellular response to testosterone stimulus; fatty acid metabolic process; ketone body biosynthetic process; liver development; positive regulation of insulin secretion; response to ethanol; response to nutrient; response to oleic acid; response to purine-containing compound; response to starvation; white fat cell differentiation
Reference #:  Q86V21 (UniProtKB)
Alt. Names/Synonyms: AACS; acetoacetate-CoA ligase; Acetoacetyl-CoA synthetase; ACSF1; Acyl-CoA synthetase family member 1; FLJ12389; FLJ41251; homolog of C. elegans supressor of ras 5 (sur-5); Protein sur-5 homolog; SUR-5
Gene Symbols: AACS
Molecular weight: 75,144 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene