ITGB3
a type 1 transmembrane protein of the integrin beta chain family. Heterodimerizes with Integrins alpha-V and alpha-IIb to bind many different ligands throughout the body, playing important roles in many signal transduction pathways. Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, von Willebrand factor , fractalkine, NRG1, FGF1, FGF2, IGF2, IL1B, PLA2G2A, and fibrillin-1. In brain, ITGAV:ITGB3 plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. ITGA2B:ITGB3 and ITGAV:ITGB3 recognize the sequence R-G-D in a wide array of ligands. ITGA2B:ITGB3 recognizes the sequence HHLGGGAKQAGDV in fibrinogen gamma chain. Following activation ITGA2B:ITGB3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets. ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9, Cytomegalovirus, Hantaan virus, Herpes virus 8, Human metapneumovirus, Human parechovirus 1, and West Nile virus. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. 3 alternatively spliced human isoforms have been reported. Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxisChromosomal Location of human Ortholog: 17q21.32
Cellular Component:
alpha9-beta1 integrin-ADAM8 complex; alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; alphav-beta3 integrin-PKCalpha complex; alphav-beta3 integrin-vitronectin complex; apical plasma membrane; cell surface; cell-cell junction; external side of plasma membrane; filopodium membrane; focal adhesion; glutamatergic synapse; glycinergic synapse; integrin alphav-beta3 complex; integrin complex; lamellipodium membrane; melanosome; microvillus membrane; nucleoplasm; nucleus; plasma membrane; platelet alpha granule membrane; postsynaptic membrane; protein-containing complex; receptor complex; ruffle membrane; synapse
Molecular Function:
C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; enzyme binding; extracellular matrix binding; fibrinogen binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; integrin binding; metal ion binding; neuregulin binding; platelet-derived growth factor receptor binding; protease binding; protein binding; protein disulfide isomerase activity; protein kinase C binding; vascular endothelial growth factor receptor 2 binding; virus receptor activity
Biological Process:
activation of protein kinase activity; angiogenesis involved in wound healing; apolipoprotein A-I-mediated signaling pathway; apoptotic cell clearance; blood coagulation; blood coagulation, fibrin clot formation; cell adhesion; cell adhesion mediated by integrin; cell migration; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; cellular response to insulin-like growth factor stimulus; cellular response to mechanical stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to xenobiotic stimulus; embryo implantation; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; maintenance of postsynaptic specialization structure; mesodermal cell differentiation; negative chemotaxis; negative regulation of endothelial cell apoptotic process; negative regulation of lipid storage; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor activity; negative regulation of macrophage derived foam cell differentiation; platelet activation; platelet aggregation; platelet-derived growth factor receptor signaling pathway; positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway; positive regulation of angiogenesis; positive regulation of bone resorption; positive regulation of cell adhesion mediated by integrin; positive regulation of cell-matrix adhesion; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glomerular mesangial cell proliferation; positive regulation of osteoblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of T cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of actin cytoskeleton organization; regulation of bone resorption; regulation of extracellular matrix organization; regulation of postsynaptic neurotransmitter receptor diffusion trapping; regulation of postsynaptic neurotransmitter receptor internalization; regulation of protein localization; regulation of protein tyrosine kinase activity; regulation of release of sequestered calcium ion into cytosol; regulation of serotonin uptake; regulation of trophoblast cell migration; response to activity; smooth muscle cell migration; substrate adhesion-dependent cell spreading; tube development; viral entry into host cell; wound healing
Disease: Bleeding Disorder, Platelet-type, 24 ; Glanzmann Thrombasthenia 2 ; Myocardial Infarction, Susceptibility To
Reference #:
P05106
(UniProtKB)
Alt. Names/Synonyms: antigen CD61; BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT; integrin beta 3; integrin beta chain, beta 3; Integrin beta-3; integrin subunit beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITB3; ITGB3; platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa
Gene Symbols: ITGB3
Molecular weight:
87,058 Da
Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
CST Pathways:
Actin Dynamics
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
Select Structure to View Below
ITGB3
1JV2 - B=27-718 (human)
1KUP - B=742-766 (human)
1KUZ - B=742-766 (human)
1L5G - B=27-718 (human)
1M1X - B=27-718 (human)
1M8O - B=742-788 (human)
1MIZ - A=765-769 (human)
1MK7 - A/C=765-775 (human)
1MK9 - A/C/E/G=765-776 (human)
1RN0 - B=135-378 (human)
1S4X - A=742-788 (human)
1TXV - B=27-466 (human)
1TY3 - B=27-466 (human)
1TY5 - B=27-466 (human)
1TY6 - B=27-466 (human)
1TY7 - B=27-466 (human)
1TYE - B/D/F=27-466 (human)
1U8C - B=27-718 (human)
2INI - B=81-460, B=558-716 (human)
2K9J - B=711-753 (human)
2KNC - B=715-788 (human)
2KV9 - B=739-788 (human)
2L1C - B=762-788 (human)
2L91 - A=711-753 (human)
2LJD - A=742-788 (human)
2LJE - A=742-788 (human)
2LJF - A=742-788 (human)
2MTP - C=742-788 (human)
2N9Y - B=712-753 (human)
2Q6W - C/F=50-61 (human)
2RMZ - A=712-753 (human)
2RN0 - A=712-753 (human)
2VC2 - B=27-487 (human)
2VDK - B=27-487 (human)
2VDL - B=27-487 (human)
2VDM - B=27-487 (human)
2VDN - B=27-487 (human)
2VDO - B=27-487 (human)
2VDP - B=27-487 (human)
2VDQ - B=27-487 (human)
2VDR - B=27-487 (human)
3FCS - B/D=27-716 (human)
3FCU - B/D/F=27-487 (human)
3IJE - B=27-721 (human)
3NID - B/D=27-497 (human)
3NIF - B/D=27-497 (human)
3NIG - B/D=27-497 (human)
3T3M - B/D=27-498 (human)
3T3P - B/D=27-498 (human)
3ZDX - B/D=27-498 (human)
3ZDY - B/D=27-498 (human)
3ZDZ - B/D=27-498 (human)
3ZE0 - B/D=27-498 (human)
3ZE1 - B/D=27-498 (human)
3ZE2 - B/D=27-498 (human)
4CAK - B=27-716 (human)
4G1E - B=27-717 (human)
4G1M - B=27-718 (human)
4HXJ - A/B=87-144 (human)
4MMX - B=27-718 (human)
4MMY - B=27-718 (human)
4MMZ - B=27-718 (human)
4O02 - B=27-718 (human)
4Z7N - D/B=29-497 (human)
4Z7O - D/B=29-497 (human)
4Z7Q - D/B=27-497 (human)
4Z7S - D/B=27-497 (human)
5HDB - D/B=27-497 (human)
6AVQ - B=27-718 (human)
6AVR - B=27-718 (human)
6AVU - B=27-718 (human)
6BXB - A/B=153-329 (human)
6BXF - A/B=153-329 (human)
6BXJ - A=153-329 (human)
6CKB - A/B=153-329 (human)
6MK0 - B=30-716 (human)
6MSL - B=27-721 (human)
6MSU - B=27-721 (human)
6NAJ - C=1539-1629 (human)
6V4P - B=1-690 (human)
7KN0 - B=712-753 (human)
7L8P - B/D=27-498 (human)
7LA4 - B=1-788 (human)
7TCT - B/D=27-498 (human)
7TD8 - B/D=27-497 (human)
7THO - B/D=27-497 (human)
7TMZ - B/D=27-497 (human)
7TPD - B/D=27-497 (human)
7U60 - B/D=27-497 (human)
7U9F - B/D=27-497 (human)
7U9V - B/D=27-497 (human)
7UBR - B/D=27-498 (human)
7UCY - B/D=27-498 (human)
7UDG - B/D=27-498 (human)
7UDH - B/D=27-498 (human)
7UE0 - B/D=27-498 (human)
7UFH - B/D=27-498 (human)
7UH8 - B/D=27-498 (human)
7UJE - B/D=27-497 (human)
7UJK - B/D=27-498 (human)
7UK9 - B/D=27-498 (human)
7UKO - B/D=27-498 (human)
7UKP - B/D=27-498 (human)
7UKT - B/D=27-498 (human)
8GCD - B=1-788 (human)
8GCE - B=1-788 (human)
8IJ5 - B=31-497 (human)
8T2U - B=27-788 (human)
8T2V - B=27-788 (human)
5XQ1 - A/B=773-787 (mouse)
6VGU - A=1-430 (mouse)
