STAP1 In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5|5 E1
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  macrophage colony-stimulating factor receptor binding; phosphotyrosine residue binding; protein binding; protein kinase binding; receptor tyrosine kinase binding; SH3/SH2 adaptor activity; signaling adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  cellular response to lipopolysaccharide; myeloid cell differentiation; negative regulation of macrophage chemotaxis; negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of microglial cell migration; negative regulation of phosphorylation; negative regulation of ruffle assembly; positive regulation of actin cytoskeleton reorganization; positive regulation of B cell receptor signaling pathway; positive regulation of gene expression; positive regulation of microglial cell activation; positive regulation of microglial cell mediated cytotoxicity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of phagocytosis, engulfment; response to bacterium; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q9JM90 (UniProtKB)
Alt. Names/Synonyms: AI586015; BCR downstream signaling 1; Brdg; Brdg1; OTTMUSP00000026072; signal transducing adaptor family member 1; Signal-transducing adaptor protein 1; STA; STAP-1; Stap1; Stem cell adaptor protein 1; stem cell adaptor protein STAP-1
Gene Symbols: Stap1
Molecular weight: 34,628 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene