STAP1 In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q13.2
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  macrophage colony-stimulating factor receptor binding; phospholipid binding; phosphotyrosine residue binding; protein binding; protein kinase binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  cellular response to lipopolysaccharide; negative regulation of macrophage chemotaxis; negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of microglial cell migration; negative regulation of phosphorylation; negative regulation of ruffle assembly; positive regulation of actin cytoskeleton reorganization; positive regulation of B cell receptor signaling pathway; positive regulation of gene expression; positive regulation of microglial cell activation; positive regulation of microglial cell mediated cytotoxicity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of phagocytosis, engulfment; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q9ULZ2 (UniProtKB)
Alt. Names/Synonyms: BCR downstream signaling 1; BCR downstream-signaling protein 1; BRDG1; Docking protein BRDG1; signal transducing adaptor family member 1; Signal-transducing adaptor protein 1; signal-transducing adaptor protein-1; STAP-1; STAP1; Stem cell adaptor protein 1
Gene Symbols: STAP1
Molecular weight: 34,291 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB