IkB-beta a protein of the NF-kappa-B inhibitor family. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. Belongs to the NF-kappa-B inhibitor family. Expressed in all tissues examined. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 7|7 B1
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  protein binding
Biological Process:  cellular response to lipopolysaccharide; cytoplasmic sequestering of NF-kappaB; signal transduction
Reference #:  Q60778 (UniProtKB)
Alt. Names/Synonyms: I(Kappa)B(beta); I-kappa-B-beta; IKapp; IkappaBbeta; IkB; IkB-B; IkB-beta; Ikbb; MGC36057; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; OTTMUSP00000018308; OTTMUSP00000018309
Gene Symbols: Nfkbib
Molecular weight: 37,965 Da
Basal Isoelectric point: 4.57  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IkB-beta

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene