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IkB-beta
a protein of the NF-kappa-B inhibitor family. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. Belongs to the NF-kappa-B inhibitor family. Expressed in all tissues examined. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor |
| Chromosomal Location of mouse Ortholog: 7|7 B1 |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
cellular response to lipopolysaccharide; cytoplasmic sequestering of NF-kappaB; inflammatory response; regulation of I-kappaB kinase/NF-kappaB signaling
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Reference #:
Q60778
(UniProtKB)
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Alt. Names/Synonyms: I(Kappa)B(beta); I-kappa-B-beta; IKapp; IkappaBbeta; IkB; IkB-B; IkB-beta; Ikbb; MGC36057; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; OTTMUSP00000018308; OTTMUSP00000018309
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Gene Symbols: Nfkbib
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Molecular weight:
37,965 Da
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Basal Isoelectric point:
4.57
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Death Receptor Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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