APC7 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC7 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  anaphase-promoting complex; nucleus
Molecular Function:  protein phosphatase binding
Biological Process:  cell cycle; cell division; protein K11-linked ubiquitination
Reference #:  Q9WVM3 (UniProtKB)
Alt. Names/Synonyms: Anapc7; anaphase promoting complex subunit 7; Anaphase-promoting complex subunit 7; APC7; AW545589; Cyclosome subunit 7; Prediabetic NOD sera-reactive autoantigen
Gene Symbols: Anapc7
Molecular weight: 63,021 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
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APC7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene