AGO4 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Belongs to the argonaute family. Ago subfamily. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 4|4 D2.2
Cellular Component:  cytoplasm; cytosol; micro-ribonucleoprotein complex; nuclear body; nucleoplasm; nucleus; P-body; RISC complex; RISC-loading complex
Molecular Function:  double-stranded RNA binding; miRNA binding; nucleic acid binding; RNA binding; single-stranded RNA binding
Biological Process:  gene silencing by RNA; male gonad development; male meiotic nuclear division; miRNA loading onto RISC involved in gene silencing by miRNA; miRNA mediated inhibition of translation; miRNA metabolic process; mRNA catabolic process; negative regulation of apoptotic process; pre-miRNA processing; production of miRNAs involved in gene silencing by miRNA; regulation of cell morphogenesis; regulation of translation; RNA secondary structure unwinding; synaptonemal complex assembly
Reference #:  Q8CJF8 (UniProtKB)
Alt. Names/Synonyms: 5730550L01Rik; Ago4; AI481660; argonaute 4; Argonaute RISC catalytic component 4; argonaute RISC catalytic subunit 4; Argonaute4; eIF-2C 4; Eif2c; eIF2C 4; Eif2c4; Eukaryotic translation initiation factor 2C 4; eukaryotic translation initiation factor 2C, 4; Kiaa1567; mAgo4; OTTMUSP00000009580; Piwi/argonaute family protein meIF2C4; Protein argonaute-4
Gene Symbols: Ago4
Molecular weight: 97,037 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene