|
AGO4
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Belongs to the argonaute family. Ago subfamily. Note: This description may include information from UniProtKB.
|
| Protein type: Translation; Translation initiation |
| Chromosomal Location of mouse Ortholog: 4|4 D2.2 |
|
Cellular Component:
cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; nucleus; P-body; ribonucleoprotein complex; RISC complex; RISC-loading complex
|
|
Molecular Function:
double-stranded RNA binding; miRNA binding; nucleic acid binding; RNA binding; RNA endonuclease activity; single-stranded RNA binding
|
|
Biological Process:
male gonad development; male meiotic nuclear division; miRNA metabolic process; miRNA processing; miRNA-mediated gene silencing by inhibition of translation; mRNA catabolic process; negative regulation of apoptotic process; pre-miRNA processing; regulation of cell morphogenesis; regulation of translation; regulatory ncRNA-mediated gene silencing; RISC complex assembly; RNA secondary structure unwinding; synaptonemal complex assembly
|
|
Reference #:
Q8CJF8
(UniProtKB)
|
|
Alt. Names/Synonyms: 5730550L01Rik; Ago4; AI481660; argonaute 4; Argonaute RISC catalytic component 4; argonaute RISC catalytic subunit 4; Argonaute4; eIF-2C 4; Eif2c; eIF2C 4; Eif2c4; Eukaryotic translation initiation factor 2C 4; eukaryotic translation initiation factor 2C, 4; Kiaa1567; mAgo4; OTTMUSP00000009580; Piwi/argonaute family protein meIF2C4; Protein argonaute-4
|
|
Gene Symbols: Ago4
|
|
Molecular weight:
97,037 Da
|
|
Basal Isoelectric point:
9.21
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
