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EHM2
Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation. Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 4 B3|4 31.66 cM |
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Cellular Component:
anchoring junction; apical part of cell; bicellular tight junction; cytoplasm; cytoskeleton; cytosol; plasma membrane
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Molecular Function:
cytoskeletal protein binding; protein binding
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Biological Process:
actomyosin structure organization; positive regulation of cell adhesion; positive regulation of gene expression; positive regulation of keratinocyte migration; wound healing
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Reference #:
Q9JMC8
(UniProtKB)
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Alt. Names/Synonyms: 6430543G08Rik; AA589614; AU021054; Band 4.1-like protein 4B; BB007528; D4Ertd346; D4Ertd346e; E41LB; Ehm2; Epb4.1l; Epb4.1l4b; Epb41l4b; erythrocyte membrane protein band 4.1 like 4b; erythrocyte protein band 4.1-like 4b; expressed in high-metastatic cells; Lul; Lulu2; OTTMUSP00000007793; OTTMUSP00000007794; Protein EHM2
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Gene Symbols: Epb41l4b
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Molecular weight:
59,564 Da
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Basal Isoelectric point:
9.38
Predict pI for various phosphorylation states
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